Are chimeric antigen receptor T cells (CAR-T cells) the long run in immunotherapy for autoimmune illnesses?
Goal: CAR-T cell remedy has revolutionized the remedy of oncological illnesses, and potential makes use of in autoimmune illnesses have just lately been described. The overview goals to combine the accessible knowledge on remedy with CAR-T cells, emphasizing autoimmune illnesses, to find out therapeutic advances and their doable future medical applicability in autoimmunity.
Supplies and strategies: A search was carried out in PubMed with the key phrases “Chimeric Antigen Receptor” and “CART cell”. The paperwork of curiosity have been chosen, and a essential overview of the data was carried out.
Outcomes: Within the remedy of autoimmune illnesses, in preclinical fashions, three completely different mobile methods have been used, which embody Chimeric antigen receptor T cells, Chimeric autoantibody receptor T cells, and Chimeric antigen receptor in regulatory T lymphocytes. All three sorts of remedy have been efficient. The potential antagonistic results inside them, cytokine launch syndrome, mobile toxicity and neurotoxicity should all the time be stored in thoughts.
Conclusions: Though info in people just isn’t but accessible, preclinical fashions of CAR-T cells within the remedy of autoimmune illnesses present promising outcomes, in order that sooner or later, they could turn out to be a helpful and efficient remedy within the remedy of those pathologies.
Ovalbumin Antigen-Particular Activation of Human T Cell Receptor Carefully Resembles Soluble Antibody Stimulation as Revealed by BOOST Phosphotyrosine Proteomics
Activation of the T cell receptor (TCR) results in a community of early signaling predominantly orchestrated by tyrosine phosphorylation in T cells. The TCR is usually activated utilizing soluble anti-TCR antibodies, however this method just isn’t antigen-specific. Alternatively, activating the TCR utilizing particular antigens of a spread of binding affinities within the type of a peptide-major histocompatibility advanced (pMHC) is presumed to be extra physiological. Nonetheless, because of the lack of wide-scale phosphotyrosine (pTyr) proteomic research straight evaluating anti-TCR antibodies and pMHC, a complete definition of those activated states stays enigmatic.
Elucidation of the tyrosine phosphoproteome utilizing quantitative pTyr proteomics permits a greater understanding of the distinctive options of those activating brokers and the position of ligand binding affinity on signaling. Right here, we apply the just lately established Broad-spectrum Optimization Of Selective Triggering (BOOST) to look at perturbations in tyrosine phosphorylation of human TCR triggered by anti-TCR antibodies and pMHC. Our knowledge reveal that high-affinity ovalbumin (OVA) pMHC activation of the human TCR triggers a largely related, albeit doubtlessly stronger, pTyr-mediated signaling regulatory axis in comparison with the anti-TCR antibody. The signaling output ensuing from OVA pMHC variants correlates properly with their weaker affinities, enabling affinity-tunable management of signaling energy. Collectively, we offer a framework for making use of BOOST to match pTyr-mediated signaling pathways of human T cells activated in an antigen-independent and antigen-specific method.
Bilateral anterior cerebral artery occlusion following CD19- and BCMA-targeted chimeric antigen receptor T-cell remedy for a myeloma affected person
Chimeric antigen receptor T (CAR-T)-cell remedy is a promising remedy for relapsed/refractory a number of myeloma (RRMM). In our earlier report, CD19- and BCMA-targeted CAR-T co-administration was related to a excessive response fee. Though cytokine launch syndrome (CRS) and neurotoxicity are frequent issues following CAR-T remedy, cerebral infarction is never reported as a CAR-T-related complication. We reported a 73-year-old feminine MM affected person who obtained CD19- and BCMA-targeted CAR-T for refractory illness.
Her illness responded to CAR-T remedy, however she developed neurological signs following CRS. Cranial CT and MRI demonstrated a number of cerebral infarctions and bilateral anterior cerebral artery (ACA) occlusion. We propose that cerebral infarction aside from CAR-T-related neurotoxicity is the underlying reason behind irregular neuropsychological signs, and diagnostic imaging assessments must be actively carried out to exclude ischemic cerebrovascular occasions.
 (CMV) (pLenti-GIII-CMV)) EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV-C-term-HA)) EBAG9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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 (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)) EBAG9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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 (CMV) (pLenti-GIII-CMV-C-term-HA)) EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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 (UbC) (pLenti-GIII-UbC)) EBAG9 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC) |
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 (EF1a) (pLenti-GIII-EF1a)) EBAG9 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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 (UbC) (pLenti-GIII-UbC)) EBAG9 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
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 (EF1a) (pLenti-GIII-EF1a)) EBAG9 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
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 (CMV) (pLenti-GIII-CMV)) HP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703719 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) C5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704421 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) XM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) XS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) S7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) CS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV709011 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) MS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) NA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV735845 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) NM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736283 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) IV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV730175 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV739457 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) NP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV814299 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701979 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) C8A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702501 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) SLN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702969 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703479 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703695 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703815 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) FGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704103 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) NNT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704253 | ABM | 1.0 ug DNA | EUR 379.2 |
LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705291 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) WSN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755987 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) WT2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755993 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) WTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755999 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) WWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756017 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) XCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756041 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) XGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756047 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) XIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756059 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) TYS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV754913 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) VCF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755573 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) VDI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755609 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) RP6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747185 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) RSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) S11 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) S12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) SDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) SEA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) PRD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) TDD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV750293 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) THM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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 (CMV) (pLenti-GIII-CMV)) TOC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV750677 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) ST2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749651 | ABM | 1.0 ug DNA | EUR 686.4 |
 (CMV) (pLenti-GIII-CMV)) ST3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749657 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) ST4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749669 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) ST8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749687 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CCT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV720665 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CCV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV720719 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CHR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721169 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CMM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721403 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CNC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721451 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) COP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721595 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CRG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721781 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CRS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721793 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CSE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721835 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) CTD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721919 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) DCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV722333 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) DDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV722357 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) EVL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV709839 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710247 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710253 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710259 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710265 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710271 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) FUZ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710289 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) GIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710403 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) GRN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710661 | ABM | 1.0 ug DNA | EUR 379.2 |
HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710829 | ABM | 1.0 ug DNA | EUR 379.2 |
HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710835 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) HYI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711141 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) JTB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711555 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) LBH Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711897 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) LTF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712071 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) LUM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712083 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) LXN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712089 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712167 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712173 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712179 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712185 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) MPI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712365 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) NF2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712731 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) NMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712773 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) BID Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707847 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707871 | ABM | 1.0 ug DNA | EUR 379.2 |
BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707877 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708255 | ABM | 1.0 ug DNA | EUR 379.2 |
CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708261 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708339 | ABM | 1.0 ug DNA | EUR 379.2 |
CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708345 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) CGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708669 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) CKB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708753 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) CRK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708987 | ABM | 1.0 ug DNA | EUR 379.2 |
CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708993 | ABM | 1.0 ug DNA | EUR 379.2 |
CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708999 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) DTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV709467 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) OAT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712983 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) OS9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713019 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) PIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713469 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) PTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713985 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) RGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV714303 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715317 | ABM | 1.0 ug DNA | EUR 379.2 |
Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715323 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) Syk Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715605 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) TK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715875 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) TTK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV716385 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) UBB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV716529 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) WAC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV716727 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) AFA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV718313 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) AIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV718391 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) AOM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV718865 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) ATD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV719171 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) DUT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV705459 | ABM | 1.0 ug DNA | EUR 540 |
NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV705585 | ABM | 1.0 ug DNA | EUR 540 |
BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV705639 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) FTO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV705999 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) MIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV706503 | ABM | 1.0 ug DNA | EUR 540 |
 (CMV) (pLenti-GIII-CMV)) AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707157 | ABM | 1.0 ug DNA | EUR 379.2 |
AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707163 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) AGK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707187 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) ALB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707271 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) ANG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707325 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) ATM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV707655 | ABM | 1.0 ug DNA | EUR 379.2 |
 (CMV) (pLenti-GIII-CMV)) FTX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV761753 | ABM | 1.0 ug DNA | EUR 1104 |
 (CMV) (pLenti-GIII-CMV)) CPP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV759281 | ABM | 1.0 ug DNA | EUR 2148 |
 (CMV) (pLenti-GIII-CMV)) CPQ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV759287 | ABM | 1.0 ug DNA | EUR 686.4 |
 (CMV) (pLenti-GIII-CMV)) MSD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV734285 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) NSX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV736493 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) NT3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV736499 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) OAP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV736655 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) OED Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV736703 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) DM1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV723179 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) DWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV723515 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) EBM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV723683 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) EGI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV723929 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) F7R Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV724757 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) FND Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV725471 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) GCY Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV726557 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) KSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730745 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) KWE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730751 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) LCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730883 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MAA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV732365 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV732641 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MEB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV732671 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) mF4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV732743 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MLS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV733631 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MOK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV733685 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) MPE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV733739 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) GTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV727145 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV728375 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) HPT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV728723 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) HTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV728969 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) JBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730193 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) JPD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730199 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) KFM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730349 | ABM | 1.0 ug DNA | Ask for price |
 (CMV) (pLenti-GIII-CMV)) KMS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730469 | ABM | 1.0 ug DNA | Ask for price |
The Intracellular Area of CD40 is a Potent Costimulatory Component in Chimeric Antigen Receptors
The costimulatory domains included into second-generation and third-generation chimeric antigen receptors (CARs) strongly affect CAR-T-cell operate. Right here, we explored second-generation and third-generation CARs harboring the signaling area of the CD40 receptor as a brand new costimulatory aspect as compared with related CARs carrying the 4-1BB area. In CARs of each generations, CD40 was stronger than 4-1BB in triggering the NF-κB signaling pathway.
In human T cells from 2 donors, CD40 was akin to 4-1BB in upregulating costimulatory and activation markers, inducing proinflammatory cytokine secretion and mediating goal cell killing. Apparently, variations within the response sample of T cells from the two donors with respect to CD40 and 4-1BB have been evident. We conclude that in human T cells, the CD40 signaling area is a potent costimulatory aspect in each second-generation and third-generation CARs.
A Systematic Overview of the Function of Chimeric Antigen Receptor T (CAR-T) Cell Remedy within the Therapy of Strong Tumors
Chimeric antigen receptor T (CAR-T) cell remedy makes use of sufferers’ personal T lymphocytes which might be engineered to assault most cancers cells. It’s Meals and Drug Administration (FDA)-approved in numerous hematological malignancies and presently being evaluated in strong cancers in early section research. We did a scientific overview consisting of 15 potential medical trials (n=159) evaluating CAR-T cells in strong cancers. Early section trials confirmed promising response charges in ovarian epithelial most cancers (100%), human epidermal progress issue receptor 2 (HER2)-positive sarcoma (67%), epidermal progress issue receptor (EGFR)-positive biliary tract most cancers (65%), superior gastric/pancreatic most cancers (82%), hepatocellular carcinoma (67%), and colorectal most cancers (70%).
The median general response throughout all malignancies was 62% (vary 17%-100%). Median progression-free survival and general survival weren’t reached in most trials. Cytokine launch syndrome was seen in just one affected person with cholangiocarcinoma who obtained EGFR-specific CAR-T cell remedy. Though survival knowledge continues to be not mature, CAR-T cell remedy in strong malignancies did present encouraging response charges and was well-tolerated.
Variations in lymphoma sufferers between chimeric antigen receptor T-cell remedy trials and the overall inhabitants
Chimeric antigen receptor (CAR)-T cell therapies seem to be promising therapies for non-Hodgkin’s and B-cell lymphoma. Nonetheless, a number of CAR-T therapies accredited by the US Meals and Drug Administration have solely been examined for efficacy in comparatively few single-arm medical trials with small pattern sizes. We sought to look at the variations between sufferers in these trials and the overall inhabitants of sufferers with non-Hodgkin’s and B-cell lymphoma. 5 hundred and twenty-two sufferers from 15 CAR-T trials present in a scientific overview and 417,492 sufferers from the Surveillance, Epidemiology, and Finish Outcomes (SEER) Program database have been in contrast.
CAR-T research individuals seemed to be youthful (46.7% beneath 70 years previous vs. 42.2%), extra male (68.0% vs. 55.7%), and adopted for a shorter time period in comparison with sufferers within the SEER inhabitants (imply [M] 45.6 months, 95% confidence interval [CI] 17.7 to 63.three months follow-up vs. M 57.1 months, 95% CI 57.Zero to 57.three months survival). CAR-T research individuals might differ considerably from the overall inhabitants of sufferers with non-Hodgkin’s and B-cell lymphoma. Effectiveness of CAR-T therapies within the common inhabitants of lymphoma sufferers might differ from effectiveness demonstrated in trials. Newly created CAR-T affected person registries are important to establishing population-level effectiveness of the therapies.
) ITGB1, 21-465aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205044-01mg | MyBiosource | 0.1mg | EUR 340 |
ITGB1, 21-465aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205044-05mg | MyBiosource | 0.5mg | EUR 765 |
ITGB1, 21-465aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205044-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 SIL1, 32-461aa, Human, His tag, E Coli |
|||
| MBS204276-001mg | MyBiosource | 0.01mg | EUR 230 |
SIL1, 32-461aa, Human, His tag, E Coli |
|||
| MBS204276-002mg | MyBiosource | 0.02mg | EUR 295 |
SIL1, 32-461aa, Human, His tag, E Coli |
|||
| MBS204276-005mg | MyBiosource | 0.05mg | EUR 350 |
SIL1, 32-461aa, Human, His tag, E Coli |
|||
| MBS204276-01mg | MyBiosource | 0.1mg | EUR 505 |
SIL1, 32-461aa, Human, His tag, E Coli |
|||
| MBS204276-025mg | MyBiosource | 0.25mg | EUR 790 |
 ODC1, 1-461aa, Human, His tag, E Coli |
|||
| MBS204706-001mg | MyBiosource | 0.01mg | EUR 230 |
ODC1, 1-461aa, Human, His tag, E Coli |
|||
| MBS204706-005mg | MyBiosource | 0.05mg | EUR 405 |
ODC1, 1-461aa, Human, His tag, E Coli |
|||
| MBS204706-025mg | MyBiosource | 0.25mg | EUR 985 |
ODC1, 1-461aa, Human, His tag, E Coli |
|||
| MBS204706-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
 ITGB1, 1-728aa, Human, His-tag, Baculovirus |
|||
| MBS206555-001mg | MyBiosource | 0.01mg | EUR 215 |
ITGB1, 1-728aa, Human, His-tag, Baculovirus |
|||
| MBS206555-002mg | MyBiosource | 0.02mg | EUR 255 |
ITGB1, 1-728aa, Human, His-tag, Baculovirus |
|||
| MBS206555-005mg | MyBiosource | 0.05mg | EUR 340 |
ITGB1, 1-728aa, Human, His-tag, Baculovirus |
|||
| MBS206555-01mg | MyBiosource | 0.1mg | EUR 470 |
ITGB1, 1-728aa, Human, His-tag, Baculovirus |
|||
| MBS206555-025mg | MyBiosource | 0.25mg | EUR 765 |
 GWB-ATG485-20UG - FSTL1, 21-308aa, Human, His tag, E.coli |
|||
| GWB-ATG485-20UG | Aviva Systems Biology | 20ug | EUR 330 |
 GWB-ATG485-100UG - FSTL1, 21-308aa, Human, His tag, E.coli |
|||
| GWB-ATG485-100UG | Aviva Systems Biology | 100ug | EUR 990 |
 Recombinant Human ITGB1 Protein, His, E.coli-10ug |
|||
| QP12462-HIS-10ug | EnQuireBio | 10ug | EUR 241.2 |
 Recombinant Human ITGB1 Protein, His, E.coli-20ug |
|||
| QP12462-HIS-20ug | EnQuireBio | 20ug | EUR 241.2 |
 ITGB1BP3, 1-230aa, Human, His tag, E Coli |
|||
| MBS204773-0004mg | MyBiosource | 0.004mg | EUR 215 |
ITGB1BP3, 1-230aa, Human, His tag, E Coli |
|||
| MBS204773-002mg | MyBiosource | 0.02mg | EUR 340 |
ITGB1BP3, 1-230aa, Human, His tag, E Coli |
|||
| MBS204773-01mg | MyBiosource | 0.1mg | EUR 765 |
ITGB1BP3, 1-230aa, Human, His tag, E Coli |
|||
| MBS204773-5x01mg | MyBiosource | 5x0.1mg | EUR 3195 |
 Recombinant Human ITGB1 Protein, His, E.coli-2ug |
|||
| QP12462-HIS-2ug | EnQuireBio | 2ug | EUR 186 |
 Recombinant Human ITGB1 Protein, His, E.coli-5ug |
|||
| QP12462-HIS-5ug | EnQuireBio | 5ug | EUR 186 |
 Recombinant Human ITGB1 Protein, His, E.coli-1mg |
|||
| QP12462-HIS-EC-1mg | EnQuireBio | 1mg | EUR 3308.4 |
) ITGB3BP, 1-216aa, Human His tag, E Coli (Denatured) |
|||
| MBS205043-0004mg | MyBiosource | 0.004mg | EUR 215 |
ITGB3BP, 1-216aa, Human His tag, E Coli (Denatured) |
|||
| MBS205043-002mg | MyBiosource | 0.02mg | EUR 340 |
ITGB3BP, 1-216aa, Human His tag, E Coli (Denatured) |
|||
| MBS205043-01mg | MyBiosource | 0.1mg | EUR 765 |
ITGB3BP, 1-216aa, Human His tag, E Coli (Denatured) |
|||
| MBS205043-5x01mg | MyBiosource | 5x0.1mg | EUR 3195 |
 Human ITGA6 & ITGB1 Protein, His Tag |
|||
| E40KMPH5766 | EnoGene | 20ug | EUR 495 |
 B2M, 21-119aa, Human, His tag, E Coli |
|||
| MBS203578-001mg | MyBiosource | 0.01mg | EUR 340 |
B2M, 21-119aa, Human, His tag, E Coli |
|||
| MBS203578-005mg | MyBiosource | 0.05mg | EUR 765 |
B2M, 21-119aa, Human, His tag, E Coli |
|||
| MBS203578-5x005mg | MyBiosource | 5x0.05mg | EUR 3195 |
 C8G, 21-202aa, Human, His tag, E Coli |
|||
| MBS204109-002mg | MyBiosource | 0.02mg | EUR 215 |
C8G, 21-202aa, Human, His tag, E Coli |
|||
| MBS204109-01mg | MyBiosource | 0.1mg | EUR 340 |
C8G, 21-202aa, Human, His tag, E Coli |
|||
| MBS204109-05mg | MyBiosource | 0.5mg | EUR 765 |
C8G, 21-202aa, Human, His tag, E Coli |
|||
| MBS204109-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 MRM1, 21-353aa, Human, His tag, E Coli |
|||
| MBS205099-001mg | MyBiosource | 0.01mg | EUR 230 |
MRM1, 21-353aa, Human, His tag, E Coli |
|||
| MBS205099-005mg | MyBiosource | 0.05mg | EUR 405 |
MRM1, 21-353aa, Human, His tag, E Coli |
|||
| MBS205099-025mg | MyBiosource | 0.25mg | EUR 985 |
MRM1, 21-353aa, Human, His tag, E Coli |
|||
| MBS205099-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
 LY6D, 21-98aa, Human, His tag, E Coli |
|||
| MBS205508-002mg | MyBiosource | 0.02mg | EUR 215 |
LY6D, 21-98aa, Human, His tag, E Coli |
|||
| MBS205508-01mg | MyBiosource | 0.1mg | EUR 340 |
LY6D, 21-98aa, Human, His tag, E Coli |
|||
| MBS205508-05mg | MyBiosource | 0.5mg | EUR 765 |
LY6D, 21-98aa, Human, His tag, E Coli |
|||
| MBS205508-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 CD40, 21-193aa, Human, His tag, E Coli |
|||
| MBS205519-001mg | MyBiosource | 0.01mg | EUR 215 |
CD40, 21-193aa, Human, His tag, E Coli |
|||
| MBS205519-005mg | MyBiosource | 0.05mg | EUR 340 |
CD40, 21-193aa, Human, His tag, E Coli |
|||
| MBS205519-025mg | MyBiosource | 0.25mg | EUR 765 |
CD40, 21-193aa, Human, His tag, E Coli |
|||
| MBS205519-5x025mg | MyBiosource | 5x0.25mg | EUR 3195 |
 CHGB, 21-677aa, Human, His tag, E Coli |
|||
| MBS203715-001mg | MyBiosource | 0.01mg | EUR 230 |
CHGB, 21-677aa, Human, His tag, E Coli |
|||
| MBS203715-005mg | MyBiosource | 0.05mg | EUR 405 |
CHGB, 21-677aa, Human, His tag, E Coli |
|||
| MBS203715-025mg | MyBiosource | 0.25mg | EUR 985 |
CHGB, 21-677aa, Human, His tag, E Coli |
|||
| MBS203715-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
 RCN3, 21-328aa, Human, His tag, E Coli |
|||
| MBS204418-002mg | MyBiosource | 0.02mg | EUR 215 |
RCN3, 21-328aa, Human, His tag, E Coli |
|||
| MBS204418-01mg | MyBiosource | 0.1mg | EUR 340 |
RCN3, 21-328aa, Human, His tag, E Coli |
|||
| MBS204418-05mg | MyBiosource | 0.5mg | EUR 765 |
RCN3, 21-328aa, Human, His tag, E Coli |
|||
| MBS204418-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 CST4, 21-141aa, Human, His tag, E Coli |
|||
| MBS204592-002mg | MyBiosource | 0.02mg | EUR 215 |
CST4, 21-141aa, Human, His tag, E Coli |
|||
| MBS204592-01mg | MyBiosource | 0.1mg | EUR 340 |
CST4, 21-141aa, Human, His tag, E Coli |
|||
| MBS204592-05mg | MyBiosource | 0.5mg | EUR 765 |
CST4, 21-141aa, Human, His tag, E Coli |
|||
| MBS204592-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 CST1, 21-141aa, Human, His tag, E Coli |
|||
| MBS204735-002mg | MyBiosource | 0.02mg | EUR 215 |
CST1, 21-141aa, Human, His tag, E Coli |
|||
| MBS204735-01mg | MyBiosource | 0.1mg | EUR 340 |
CST1, 21-141aa, Human, His tag, E Coli |
|||
| MBS204735-05mg | MyBiosource | 0.5mg | EUR 765 |
CST1, 21-141aa, Human, His tag, E Coli |
|||
| MBS204735-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 LCN2, 21-198aa, Human, His tag, E Coli |
|||
| MBS203944-002mg | MyBiosource | 0.02mg | EUR 230 |
LCN2, 21-198aa, Human, His tag, E Coli |
|||
| MBS203944-01mg | MyBiosource | 0.1mg | EUR 405 |
LCN2, 21-198aa, Human, His tag, E Coli |
|||
| MBS203944-05mg | MyBiosource | 0.5mg | EUR 985 |
LCN2, 21-198aa, Human, His tag, E Coli |
|||
| MBS203944-5x05mg | MyBiosource | 5x0.5mg | EUR 4180 |
 AGRP, 21-132aa, Human, His tag, E Coli |
|||
| MBS206129-001mg | MyBiosource | 0.01mg | EUR 205 |
AGRP, 21-132aa, Human, His tag, E Coli |
|||
| MBS206129-002mg | MyBiosource | 0.02mg | EUR 250 |
AGRP, 21-132aa, Human, His tag, E Coli |
|||
| MBS206129-005mg | MyBiosource | 0.05mg | EUR 285 |
AGRP, 21-132aa, Human, His tag, E Coli |
|||
| MBS206129-01mg | MyBiosource | 0.1mg | EUR 380 |
AGRP, 21-132aa, Human, His tag, E Coli |
|||
| MBS206129-025mg | MyBiosource | 0.25mg | EUR 580 |
 PDIA4, 21-645aa, Human, His tag, E Coli |
|||
| MBS203661-001mg | MyBiosource | 0.01mg | EUR 230 |
PDIA4, 21-645aa, Human, His tag, E Coli |
|||
| MBS203661-005mg | MyBiosource | 0.05mg | EUR 405 |
PDIA4, 21-645aa, Human, His tag, E Coli |
|||
| MBS203661-025mg | MyBiosource | 0.25mg | EUR 985 |
PDIA4, 21-645aa, Human, His tag, E Coli |
|||
| MBS203661-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
 TREM1, 21-205aa, Human, His tag, E Coli |
|||
| MBS204245-002mg | MyBiosource | 0.02mg | EUR 215 |
TREM1, 21-205aa, Human, His tag, E Coli |
|||
| MBS204245-01mg | MyBiosource | 0.1mg | EUR 340 |
TREM1, 21-205aa, Human, His tag, E Coli |
|||
| MBS204245-05mg | MyBiosource | 0.5mg | EUR 765 |
TREM1, 21-205aa, Human, His tag, E Coli |
|||
| MBS204245-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 FSTL1, 21-308aa, Human, His tag, E Coli |
|||
| MBS204927-001mg | MyBiosource | 0.01mg | EUR 240 |
FSTL1, 21-308aa, Human, His tag, E Coli |
|||
| MBS204927-002mg | MyBiosource | 0.02mg | EUR 320 |
FSTL1, 21-308aa, Human, His tag, E Coli |
|||
| MBS204927-005mg | MyBiosource | 0.05mg | EUR 375 |
FSTL1, 21-308aa, Human, His tag, E Coli |
|||
| MBS204927-01mg | MyBiosource | 0.1mg | EUR 550 |
FSTL1, 21-308aa, Human, His tag, E Coli |
|||
| MBS204927-025mg | MyBiosource | 0.25mg | EUR 885 |
 MSRB3, 21-185aa, Human, His tag, E Coli |
|||
| MBS203811-001mg | MyBiosource | 0.01mg | EUR 230 |
MSRB3, 21-185aa, Human, His tag, E Coli |
|||
| MBS203811-005mg | MyBiosource | 0.05mg | EUR 405 |
MSRB3, 21-185aa, Human, His tag, E Coli |
|||
| MBS203811-025mg | MyBiosource | 0.25mg | EUR 985 |
MSRB3, 21-185aa, Human, His tag, E Coli |
|||
| MBS203811-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
 PSMB9, 21-219aa, Human, His tag, E Coli |
|||
| MBS203848-001mg | MyBiosource | 0.01mg | EUR 215 |
PSMB9, 21-219aa, Human, His tag, E Coli |
|||
| MBS203848-005mg | MyBiosource | 0.05mg | EUR 340 |
PSMB9, 21-219aa, Human, His tag, E Coli |
|||
| MBS203848-025mg | MyBiosource | 0.25mg | EUR 765 |
PSMB9, 21-219aa, Human, His tag, E Coli |
|||
| MBS203848-5x025mg | MyBiosource | 5x0.25mg | EUR 3195 |
 MSRB2, 21-182aa, Human, His tag, E Coli |
|||
| MBS203879-002mg | MyBiosource | 0.02mg | EUR 215 |
MSRB2, 21-182aa, Human, His tag, E Coli |
|||
| MBS203879-01mg | MyBiosource | 0.1mg | EUR 340 |
MSRB2, 21-182aa, Human, His tag, E Coli |
|||
| MBS203879-05mg | MyBiosource | 0.5mg | EUR 765 |
MSRB2, 21-182aa, Human, His tag, E Coli |
|||
| MBS203879-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 BOLA1, 21-137aa, Human, His tag, E Coli |
|||
| MBS205376-002mg | MyBiosource | 0.02mg | EUR 215 |
BOLA1, 21-137aa, Human, His tag, E Coli |
|||
| MBS205376-01mg | MyBiosource | 0.1mg | EUR 340 |
BOLA1, 21-137aa, Human, His tag, E Coli |
|||
| MBS205376-05mg | MyBiosource | 0.5mg | EUR 765 |
BOLA1, 21-137aa, Human, His tag, E Coli |
|||
| MBS205376-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 MuCL1, 21-90aa, Human, His tag, E Coli |
|||
| MBS205906-0004mg | MyBiosource | 0.004mg | EUR 215 |
MuCL1, 21-90aa, Human, His tag, E Coli |
|||
| MBS205906-002mg | MyBiosource | 0.02mg | EUR 340 |
MuCL1, 21-90aa, Human, His tag, E Coli |
|||
| MBS205906-01mg | MyBiosource | 0.1mg | EUR 765 |
MuCL1, 21-90aa, Human, His tag, E Coli |
|||
| MBS205906-5x01mg | MyBiosource | 5x0.1mg | EUR 3195 |
 HS3ST1, 21-307aa, Human, His tag, E Coli |
|||
| MBS205156-001mg | MyBiosource | 0.01mg | EUR 215 |
HS3ST1, 21-307aa, Human, His tag, E Coli |
|||
| MBS205156-005mg | MyBiosource | 0.05mg | EUR 340 |
HS3ST1, 21-307aa, Human, His tag, E Coli |
|||
| MBS205156-025mg | MyBiosource | 0.25mg | EUR 765 |
HS3ST1, 21-307aa, Human, His tag, E Coli |
|||
| MBS205156-5x025mg | MyBiosource | 5x0.25mg | EUR 3195 |
 Midkine, 21-143aa, Human, His tag, E Coli |
|||
| MBS203354-002mg | MyBiosource | 0.02mg | EUR 215 |
Midkine, 21-143aa, Human, His tag, E Coli |
|||
| MBS203354-01mg | MyBiosource | 0.1mg | EUR 340 |
Midkine, 21-143aa, Human, His tag, E Coli |
|||
| MBS203354-05mg | MyBiosource | 0.5mg | EUR 765 |
Midkine, 21-143aa, Human, His tag, E Coli |
|||
| MBS203354-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 DEFB118, 21-123aa, Human, His tag, E Coli |
|||
| MBS204950-002mg | MyBiosource | 0.02mg | EUR 215 |
DEFB118, 21-123aa, Human, His tag, E Coli |
|||
| MBS204950-01mg | MyBiosource | 0.1mg | EUR 340 |
DEFB118, 21-123aa, Human, His tag, E Coli |
|||
| MBS204950-05mg | MyBiosource | 0.5mg | EUR 765 |
DEFB118, 21-123aa, Human, His tag, E Coli |
|||
| MBS204950-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 Vaspin, 21- 414aa, Human, His tag, E Coli |
|||
| MBS203100-002mg | MyBiosource | 0.02mg | EUR 275 |
Vaspin, 21- 414aa, Human, His tag, E Coli |
|||
| MBS203100-01mg | MyBiosource | 0.1mg | EUR 550 |
Vaspin, 21- 414aa, Human, His tag, E Coli |
|||
| MBS203100-05mg | MyBiosource | 0.5mg | EUR 1410 |
Vaspin, 21- 414aa, Human, His tag, E Coli |
|||
| MBS203100-5x05mg | MyBiosource | 5x0.5mg | EUR 6110 |
 Human Integrin b1 / ITGB1 / CD29, His Tag |
|||
| E24PHA397 | EnoGene | 50 μg | EUR 332 |
 Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag |
|||
| MBS189055-001mg | MyBiosource | 0.01mg | EUR 235 |
Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag |
|||
| MBS189055-005mg | MyBiosource | 0.05mg | EUR 435 |
Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag |
|||
| MBS189055-5x005mg | MyBiosource | 5x0.05mg | EUR 1655 |
 AGR 2, 21-175aa, Human, His tag, E Coli |
|||
| MBS203107-002mg | MyBiosource | 0.02mg | EUR 215 |
AGR 2, 21-175aa, Human, His tag, E Coli |
|||
| MBS203107-01mg | MyBiosource | 0.1mg | EUR 340 |
AGR 2, 21-175aa, Human, His tag, E Coli |
|||
| MBS203107-05mg | MyBiosource | 0.5mg | EUR 765 |
AGR 2, 21-175aa, Human, His tag, E Coli |
|||
| MBS203107-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
 SAA,4, 21-130aa, Human, His tag, E Coli |
|||
| MBS203993-001mg | MyBiosource | 0.01mg | EUR 240 |
SAA,4, 21-130aa, Human, His tag, E Coli |
|||
| MBS203993-002mg | MyBiosource | 0.02mg | EUR 320 |
SAA,4, 21-130aa, Human, His tag, E Coli |
|||
| MBS203993-005mg | MyBiosource | 0.05mg | EUR 375 |
SAA,4, 21-130aa, Human, His tag, E Coli |
|||
| MBS203993-01mg | MyBiosource | 0.1mg | EUR 550 |
SAA,4, 21-130aa, Human, His tag, E Coli |
|||
| MBS203993-025mg | MyBiosource | 0.25mg | EUR 885 |
 Human ITGA8 & ITGB1 Protein, His & Flag Tag |
|||
| E40KMPH5768 | EnoGene | 20ug | EUR 495 |
 Recombinant Human ITGB1 protein, N - His tag |
|||
| MBS157667-005mg | MyBiosource | 0.05mg | EUR 320 |
Recombinant Human ITGB1 protein, N - His tag |
|||
| MBS157667-01mg | MyBiosource | 0.1mg | EUR 410 |
Recombinant Human ITGB1 protein, N - His tag |
|||
| MBS157667-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
 Recombinant Human CD29/ITGB1 Protein, His Tag |
|||
| E40KMH184 | EnoGene | 20ug | EUR 495 |
, 21-226aa, Human, His tag, E Coli) GPX3 (u73C), 21-226aa, Human, His tag, E Coli |
|||
| MBS204302-001mg | MyBiosource | 0.01mg | EUR 230 |
GPX3 (u73C), 21-226aa, Human, His tag, E Coli |
|||
| MBS204302-005mg | MyBiosource | 0.05mg | EUR 405 |
GPX3 (u73C), 21-226aa, Human, His tag, E Coli |
|||
| MBS204302-025mg | MyBiosource | 0.25mg | EUR 985 |
GPX3 (u73C), 21-226aa, Human, His tag, E Coli |
|||
| MBS204302-5x025mg | MyBiosource | 5x0.25mg | EUR 4180 |
) CGB, 21-165aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205434-002mg | MyBiosource | 0.02mg | EUR 215 |
CGB, 21-165aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205434-01mg | MyBiosource | 0.1mg | EUR 340 |
CGB, 21-165aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205434-05mg | MyBiosource | 0.5mg | EUR 765 |
CGB, 21-165aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205434-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
) ITGB1 protein (His tag) |
|||
| 80R-3617 | Fitzgerald | 100 ug | EUR 337 |
|
Description: Purified recombinant ITGB1 protein (His tag) |
|||
) ARSA, 21-509aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205081-002mg | MyBiosource | 0.02mg | EUR 215 |
ARSA, 21-509aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205081-01mg | MyBiosource | 0.1mg | EUR 340 |
ARSA, 21-509aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205081-05mg | MyBiosource | 0.5mg | EUR 765 |
ARSA, 21-509aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205081-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
) CD27, 21-191aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204711-002mg | MyBiosource | 0.02mg | EUR 215 |
CD27, 21-191aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204711-01mg | MyBiosource | 0.1mg | EUR 340 |
CD27, 21-191aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204711-05mg | MyBiosource | 0.5mg | EUR 765 |
CD27, 21-191aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204711-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
) JAM2, 21-238aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204951-002mg | MyBiosource | 0.02mg | EUR 215 |
JAM2, 21-238aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204951-01mg | MyBiosource | 0.1mg | EUR 340 |
JAM2, 21-238aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204951-05mg | MyBiosource | 0.5mg | EUR 765 |
JAM2, 21-238aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204951-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
) TSHB, 21-138aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204965-0004mg | MyBiosource | 0.004mg | EUR 215 |
TSHB, 21-138aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204965-002mg | MyBiosource | 0.02mg | EUR 340 |
TSHB, 21-138aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204965-01mg | MyBiosource | 0.1mg | EUR 765 |
TSHB, 21-138aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204965-5x01mg | MyBiosource | 5x0.1mg | EUR 3195 |
) uGT8, 21-541aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205035-002mg | MyBiosource | 0.02mg | EUR 215 |
uGT8, 21-541aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205035-01mg | MyBiosource | 0.1mg | EUR 340 |
uGT8, 21-541aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205035-05mg | MyBiosource | 0.5mg | EUR 765 |
uGT8, 21-541aa, Human, His tag, E Coli (Denatured) |
|||
| MBS205035-5x05mg | MyBiosource | 5x0.5mg | EUR 3195 |
) IL34, 21-242aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204822-001mg | MyBiosource | 0.01mg | EUR 215 |
IL34, 21-242aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204822-002mg | MyBiosource | 0.02mg | EUR 255 |
IL34, 21-242aa, Human, His tag, E Coli (Denatured) |
|||
| MBS204822-005mg | MyBiosource | 0.05mg | EUR 340 |